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KMID : 0613820140240040352
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Journal of Life Science
2014 Volume.24 No. 4 p.352 ~ p.360
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Effects of Dietary Probiotics as an Alternative to Antibiotics on Growth Performance, Biochemical Characteristics and Immune Response in Weaning Pigs
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Lee Sang-Bum
Lee Jae-Sung
Wang Tao
Kim Min-Jeong
Jung Woo-Suk
Jeon Seung-Woo
Park Yun-Jeong
Shin Teak-Soon
Park Sang-Hong
Lee Hong-Gu
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Abstract
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We evaluated the growth performance, biochemical characteristics, and immune responses in weaning pigs given a diet containing MR-1 (0.2%/feed) or antibiotics (0.1%/feed) for 45 days. In vitro study showed that MR-1 has antibacterial activity against a variety of strains of pathogenic bacteria, especially a strain of cattle-derived Escherichia coli K99 (E. coli K99) by agar diffusion assay. In the in vivo model, 0.2% MR-1-given group clearly ameliorated the weight gain and feed efficiency in the growth performance of weaning pigs compared to the basal diet group (p<0.05). Additionally, 0.2% MR-1 induced an elevation in the levels of mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) and showed a similar pattern (TNFα and IFNγ production) to the antibiotic treated pigs. Taken together, we suggest that 0.2% MR-1 makes probiotics an alternative to antibiotics in weaning pigs.
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KEYWORD
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Antibacterial activity, biochemical characteristics, cytokine production, probiotics, weaning pigs
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